Developing an Okayness with Suffering?

I think much of my time is devoted to trying to develop an okayness with suffering using a variety of frameworks... A search for meaning and purpose, with the hope that any kind of discomfort "is worth experiencing" for the sake of some kind of purpose/goal. Or using religious frameworks of surrender and letting go, in hopes of entering into a different state of being where the experience of suffering is something to be sat with until it is changed (with secret hopes of transmutation). Or using quotes like "and this too shall pass" creating patience to wait it out. Or the idea of training and enduring for the sake of a hoped for goal, a kind of quest to reach a different level through one's constant efforts. Or using an experience and channeling the residual energy of it, in order to create something that will perhaps be of benefit to myself or to others... Or to use an experience as the basis for empathy and understanding for others... Lately I've been trying to frame suffering in terms of our animal nature, where many of our instincts drive us in one direction or another, affecting our neurotransmitters. The idea that pleasure or discomfort are a kind of guide toward survival, and that there are going to be experiences of ups and downs because of our chemical systems. Overall, I guess my main strategy of seeking okayness is the desire to make suffering count for something. In this way, I am goal orientated... I want some kind of result... yet still lingering in my thoughts is a fear that there is no purpose... A fear that all of the experience is in vain...